Best peptides for gut health
Peptides that support gut lining repair, reduce intestinal inflammation, and improve digestive function.
What to know
BPC-157 is the standout peptide for gut health — originally isolated from gastric juice, it has extensive animal data showing gut lining repair, anti-inflammatory effects, and protection against NSAID-induced damage. Oral BPC-157 may be most effective for gut-specific issues. Larazotide targets tight junction integrity (relevant for celiac and leaky gut). LL-37 has antimicrobial properties. Most gut peptide protocols run 4-8 weeks.
Recommended peptides
BPC-157
BPC-157
BPC-157 (Body Protection Compound-157) is a synthetic peptide derived from a protein found in human gastric juice. It has shown remarkable healing properties in preclinical studies across tendons, ligaments, muscle, gut, and nervous system tissue.
LL-37
LL-37 is a human antimicrobial peptide (cathelicidin) that plays a key role in innate immune defense against bacteria, viruses, and fungi.
Recommended stacks
GLP-1 Weight Loss Stack
beginner — $200-600 (compounded) or $1,000+ (brand)
The foundational weight loss protocol using GLP-1 receptor agonists with muscle preservation support. The most evidence-backed approach to significant weight loss.
Gut Restoration Stack
beginner — $80-160
Targeted gut healing protocol for leaky gut, IBS, GERD, or post-antibiotic gut repair using oral and injectable peptides.
Explore other goals
Weekly peptide research updates
New studies, GLP-1 news, protocol insights, and weight loss data — delivered every week. Free. No spam.
Reviewed by Fat Man in the Arena · Updated March 2026