The Fat Loss Stack
A triple-compound approach to fat loss that works through three distinct mechanisms: AOD-9604 mimics the fat-burning fragment of growth hormone, tesamorelin targets visceral fat through GHRH receptor activation, and MOTS-c optimizes mitochondrial metabolism.
Difficulty
advanced
Est. Cost
$350-700
Duration
8-12 weeks
Peptides
3 compounds
Protocol
| Peptide | Dose | Frequency | Timing | Role |
|---|---|---|---|---|
| AOD-9604 | 300mcg | Once daily | Morning, empty stomach | HGH fragment 176-191 analog that stimulates lipolysis without GH side effects |
| Tesamorelin | 2mg | Once daily | Morning, 30 min after AOD-9604 | GHRH analog for targeted visceral adipose tissue reduction |
| MOTS-c | 10mg | 3x per week | Morning before exercise | Mitochondrial-derived peptide that activates AMPK and acts as exercise mimetic |
Notes
This stack attacks fat from three angles: AOD-9604 directly stimulates fat cell breakdown, tesamorelin targets the dangerous visceral fat around organs, and MOTS-c improves how your mitochondria burn fuel. All three should be taken on empty stomach in the morning. AOD-9604 first, tesamorelin 30 minutes later, MOTS-c before exercise on training days. This is an advanced protocol. Consider running the simpler semaglutide + tesamorelin stack first if you are new to peptides. Caloric deficit, high protein, and resistance training remain essential.
Related goals
Related Comparisons
MOTS-c vs AOD-9604: Metabolic Peptides for Fat Loss Compared
AOD-9604 vs Semaglutide: Research Peptide vs FDA-Approved GLP-1
AOD-9604 vs Tesamorelin: Which Fat-Targeting Peptide Is Better?
Tesamorelin vs Ipamorelin: Which GH Peptide Is Right for You?
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Written by Alejandro Reyes
Founder & Lead Researcher
Reviewed by Peptide Nerds Editorial · Updated March 2026
Medical Disclaimer: Peptide stacks are not FDA-approved protocols. This information is for educational purposes only. Consult a qualified healthcare provider before combining any peptides.