Best peptides for weight loss
Peptides that suppress appetite, increase metabolic rate, or enhance fat oxidation to support significant weight loss.
What to know
GLP-1 receptor agonists (semaglutide, tirzepatide) have the strongest clinical evidence for weight loss. FDA-approved options exist. Expect GI side effects during dose titration. Muscle preservation requires concurrent resistance training and adequate protein intake (1g/lb). Consider metabolic peptides like MOTS-c as adjuncts for those already on GLP-1 therapy.
Recommended peptides
Semaglutide
Semaglutide is a GLP-1 receptor agonist originally developed for type 2 diabetes that has demonstrated significant weight loss effects in clinical trials. It is sold under the brand names Ozempic (diabetes) and Wegovy (weight management).
Tirzepatide
Tirzepatide is a dual GIP/GLP-1 receptor agonist that has shown greater weight loss than semaglutide in head-to-head trials. It is sold under the brand names Mounjaro (diabetes) and Zepbound (weight management).
Retatrutide
Retatrutide is a triple hormone receptor agonist (GIP/GLP-1/glucagon) currently in Phase 3 clinical trials. Early data shows up to 24% body weight loss, potentially making it the most effective weight loss peptide ever studied.
AOD-9604
AOD-9604 is a modified fragment of human growth hormone (hGH fragment 176-191) that stimulates fat breakdown without the growth-promoting effects of full HGH.
MOTS-c
MOTS-c
MOTS-c is a mitochondrial-derived peptide that regulates metabolic homeostasis and has been called an "exercise mimetic" for its ability to activate AMPK pathways.
Tesamorelin
Tesamorelin is a GHRH analog FDA-approved for reducing excess abdominal fat in HIV-associated lipodystrophy. It is the only FDA-approved GH secretagogue currently available.
Recommended stacks
GLP-1 Weight Loss Stack
beginner — $200-600 (compounded) or $1,000+ (brand)
The foundational weight loss protocol using GLP-1 receptor agonists with muscle preservation support. The most evidence-backed approach to significant weight loss.
Dual Agonist Fat Loss Stack
intermediate — $300-800
Tirzepatide-based protocol leveraging dual GLP-1/GIP receptor activation for maximum weight loss with metabolic support.
Weight Loss + Healing Combo
intermediate — $300-700
For people who need to lose weight but also have injuries or joint pain that limit exercise. Addresses both simultaneously.
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Reviewed by Fat Man in the Arena · Updated March 2026