The Weight Loss Stack
Combines the appetite-suppressing power of semaglutide with tesamorelin's targeted visceral fat reduction. Semaglutide reduces caloric intake through GLP-1 receptor activation while tesamorelin specifically targets the deep abdominal fat linked to metabolic disease.
Difficulty
intermediate
Est. Cost
$400-1,200
Duration
6-12 months
Peptides
2 compounds
Protocol
| Peptide | Dose | Frequency | Timing | Role |
|---|---|---|---|---|
| Semaglutide | 0.25-2.4mg | Once weekly | Same day each week, any time | GLP-1 receptor agonist for appetite suppression and metabolic improvement |
| Tesamorelin | 2mg | Once daily | Morning, empty stomach | GHRH analog targeting visceral adipose tissue reduction |
Notes
Semaglutide handles the appetite and caloric intake side. Tesamorelin is FDA-approved (as Egrifta) for reducing visceral fat in HIV-associated lipodystrophy and has strong data for visceral fat reduction in broader populations. Start semaglutide at 0.25mg and titrate every 4 weeks. Tesamorelin should be taken on an empty stomach (no food 2 hours before, 30 min after). High protein intake (1g per pound bodyweight) and resistance training 3-4x/week are essential to preserve lean mass during rapid weight loss.
Related goals
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Semaglutide vs Tirzepatide: Which GLP-1 Is Better for Weight Loss?
Semaglutide vs Retatrutide: Single vs Triple Agonist Compared
Semaglutide vs Liraglutide: Weekly vs Daily GLP-1 for Weight Loss
Semaglutide vs Survodutide: GLP-1 vs GLP-1/Glucagon Dual Agonist
Ozempic vs Wegovy: Same Drug, Different Doses — What You Need to Know
Retatrutide vs Tirzepatide vs Semaglutide: Triple vs Dual vs Single Agonist
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Free Peptide Weight Loss Guide
Semaglutide vs. tirzepatide vs. retatrutide. Dosing protocols, side effects, gray market sourcing, and what the clinical trials found.
Written by Alejandro Reyes
Founder & Lead Researcher
Reviewed by Peptide Nerds Editorial · Updated March 2026
Medical Disclaimer: Peptide stacks are not FDA-approved protocols. This information is for educational purposes only. Consult a qualified healthcare provider before combining any peptides.