Evidence-Based Peptide Research
The peptide weight loss guide
Everything you need to know about GLP-1 peptides for weight loss. Compare semaglutide, tirzepatide, and retatrutide side by side. Research-backed dosing, side effects, cost breakdowns, and tools.
GLP-1 weight loss peptides
The most effective peptides for significant weight loss, ranked by clinical evidence.
Semaglutide
Semaglutide is a GLP-1 receptor agonist originally developed for type 2 diabetes that has demonstrated significant weight loss effects in clinical trials. It is sold under the brand names Ozempic (diabetes) and Wegovy (weight management).
Tirzepatide
Tirzepatide is a dual GIP/GLP-1 receptor agonist that has shown greater weight loss than semaglutide in head-to-head trials. It is sold under the brand names Mounjaro (diabetes) and Zepbound (weight management).
Retatrutide
Retatrutide is a triple hormone receptor agonist (GIP/GLP-1/glucagon) currently in Phase 3 clinical trials. Early data shows up to 24% body weight loss, potentially making it the most effective weight loss peptide ever studied.
Liraglutide
Liraglutide is an older GLP-1 receptor agonist requiring daily injection. Sold as Victoza (diabetes) and Saxenda (weight loss), it has been largely superseded by weekly semaglutide but remains widely prescribed.
Survodutide
Survodutide is a dual GLP-1/glucagon receptor agonist developed by Boehringer Ingelheim, currently in Phase 3 trials for obesity and metabolic liver disease.
Which GLP-1 is right for you?
Side-by-side comparisons of the top weight loss peptides.
Semaglutide vs Tirzepatide: Which GLP-1 Is Better for Weight Loss?
Compare semaglutide (Ozempic/Wegovy) vs tirzepatide (Mounjaro/Zepbound) for weight loss. Side-by-side analysis of effectiveness, side effects, cost, and availability.
Semaglutide vs Retatrutide: Single vs Triple Agonist Compared
Compare semaglutide (GLP-1) vs retatrutide (triple agonist GLP-1/GIP/glucagon). Effectiveness, research status, and what the Phase 2 data shows.
Tirzepatide vs Retatrutide: Dual vs Triple Agonist for Weight Loss
Compare tirzepatide (dual GLP-1/GIP) vs retatrutide (triple GLP-1/GIP/glucagon). Which next-gen peptide offers more weight loss potential?
Semaglutide vs Liraglutide: Weekly vs Daily GLP-1 for Weight Loss
Compare semaglutide (Wegovy, weekly) vs liraglutide (Saxenda, daily) for weight loss. Efficacy, convenience, side effects, and cost breakdown.
Ozempic vs Wegovy: Same Drug, Different Doses — What You Need to Know
Ozempic and Wegovy are both semaglutide. Learn the key differences in dosing, FDA approval, insurance coverage, and which one is prescribed for weight loss.
Compounded vs Brand-Name Semaglutide: Price, Safety, and Legality
Compare compounded semaglutide ($150-500/mo) vs brand-name Ozempic/Wegovy ($1,000+/mo). Is compounded semaglutide safe, legal, and effective?
Peptides that support weight loss
Manage GLP-1 side effects, preserve muscle, and optimize fat loss with these complementary compounds.
BPC-157
BPC-157
BPC-157 (Body Protection Compound-157) is a synthetic peptide derived from a protein found in human gastric juice. It has shown remarkable healing properties in preclinical studies across tendons, ligaments, muscle, gut, and nervous system tissue.
Tesamorelin
Tesamorelin is a GHRH analog FDA-approved for reducing excess abdominal fat in HIV-associated lipodystrophy. It is the only FDA-approved GH secretagogue currently available.
AOD-9604
AOD-9604 is a modified fragment of human growth hormone (hGH fragment 176-191) that stimulates fat breakdown without the growth-promoting effects of full HGH.
MOTS-c
MOTS-c
MOTS-c is a mitochondrial-derived peptide that regulates metabolic homeostasis and has been called an "exercise mimetic" for its ability to activate AMPK pathways.
Find peptides by goal
Weight loss is the starting point. What else do you need?
Weight Loss
Peptides that suppress appetite, increase metabolic rate, or enhance fat oxidation to support significant weight loss.
6 peptides →
Muscle Growth
Peptides that stimulate growth hormone release, enhance recovery, or support lean tissue development for building muscle.
6 peptides →
Fat Loss
Peptides that target fat metabolism specifically, including visceral fat reduction and improved body composition without necessarily lowering scale weight.
6 peptides →
Gut Health
Peptides that support gut lining repair, reduce intestinal inflammation, and improve digestive function.
4 peptides →
Weekly peptide research updates
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