Liraglutide
Written by Alejandro Reyes
Founder & Lead Researcher
Reviewed by Peptide Nerds Editorial · Updated April 2026
Key Takeaway
Liraglutide is an older GLP-1 receptor agonist requiring daily injection. Sold as Victoza (diabetes) and Saxenda (weight loss), it has been largely superseded by weekly semaglutide but remains widely prescribed.
| Type | GLP-1 / Weight Loss |
| FDA Status | FDA Approved |
| Evidence Level | Strong |
| Typical Dose | 3.0 mg daily |
| Frequency | Once daily subcutaneous injection |
| Key Goals | weight-loss |
How it works
Liraglutide activates the GLP-1 receptor to reduce appetite, slow gastric emptying, and improve insulin secretion. It shares the same mechanism as semaglutide but has a shorter half-life requiring daily dosing.
Benefits
- FDA-approved for weight management
- Well-studied safety profile
- Available in daily injection pen format
Side effects
- Nausea
- Diarrhea
- Constipation
- Headache
- Low blood sugar risk when combined with insulin
Dosing protocol
Typical Dose
3.0 mg daily
Frequency
Once daily subcutaneous injection
Titrate from 0.6 mg daily, increasing by 0.6 mg weekly.
Deeper on Liraglutide
Full breakdowns of every part of the Liraglutide research base.
What you will need
Basic supplies for reconstitution and subcutaneous injection.
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Bacteriostatic Water (30mL)
$8-15Required for reconstituting lyophilized peptides. 30mL is standard.
Insulin Syringes (1mL, 29ga)
$12-20 (100ct)1mL insulin syringes with 29-gauge needles for subcutaneous injection.
Alcohol Prep Pads
$5-10 (200ct)Sterile 70% isopropyl alcohol wipes for injection site prep.
Sharps Container
$8-15FDA-cleared sharps disposal container for used needles.
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Key research
A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management (SCALE)
New England Journal of Medicine (2015) — PubMed
8% mean body weight loss over 56 weeks vs 2.6% placebo.
FDA status
FDA Approved for: Type 2 diabetes (Victoza), weight management (Saxenda)
Where to get Liraglutide
Liraglutide requires a prescription. These telehealth platforms offer online consultations and home delivery.
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Dosing quick-reference, key studies, and side effect management — in your inbox.
Frequently asked questions
How does liraglutide compare to semaglutide?
Semaglutide produces roughly twice the weight loss of liraglutide (14.9% vs 8%) and only requires weekly injection versus daily. Most physicians now prefer semaglutide for weight management. Liraglutide remains an option for patients who prefer daily dosing or cannot tolerate semaglutide.
Compare Liraglutide
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Medical Disclaimer: This content is for informational and educational purposes only. It is not intended as medical advice or a substitute for professional medical consultation, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide protocol.