Best peptides for anti-aging
Peptides that support longevity markers, skin health, cognitive function, and overall healthspan extension.
What to know
GHK-Cu has the strongest topical anti-aging evidence (collagen synthesis, wound healing, gene modulation). Epithalon targets telomere extension through telomerase activation — research is promising but early. MOTS-c and SS-31 target mitochondrial function, which declines with age. Anti-aging peptide protocols tend to be longer-term (6+ months) and stack multiple compounds targeting different aging pathways.
Recommended peptides
GHK-Cu
GHK-Cu
GHK-Cu (copper peptide) is a naturally occurring tripeptide bound to copper that declines with age. It is one of the most well-researched peptides for skin regeneration, wound healing, and anti-aging, with over 60 years of published research.
BPC-157
BPC-157
BPC-157 (Body Protection Compound-157) is a synthetic peptide derived from a protein found in human gastric juice. It has shown remarkable healing properties in preclinical studies across tendons, ligaments, muscle, gut, and nervous system tissue.
SS-31
SS-31
SS-31 (Elamipretide) is a mitochondria-targeted peptide that restores mitochondrial function and has been studied in clinical trials for heart failure and mitochondrial diseases.
MOTS-c
MOTS-c
MOTS-c is a mitochondrial-derived peptide that regulates metabolic homeostasis and has been called an "exercise mimetic" for its ability to activate AMPK pathways.
Recommended stacks
GH Optimization Stack
intermediate — $100-250
Growth hormone secretagogue stack combining GHRP and GHRH for synergistic GH release without exogenous HGH.
Anti-Aging Longevity Stack
advanced — $300-600
Multi-pathway anti-aging protocol targeting telomeres, mitochondrial function, skin health, and immune modulation.
Skin Rejuvenation Stack
beginner — $80-200
Targeted skin health protocol combining topical and systemic peptides for collagen production, wrinkle reduction, and skin repair.
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Reviewed by Fat Man in the Arena · Updated March 2026