MOTS-c
(MOTS-c)
Written by Alejandro Reyes
Founder & Lead Researcher
Reviewed by Peptide Nerds Editorial · Updated April 2026
Key Takeaway
MOTS-c is a mitochondrial-derived peptide that regulates metabolic homeostasis and has been called an "exercise mimetic" for its ability to activate AMPK pathways.
| Type | Metabolic |
| FDA Status | Research Only |
| Evidence Level | Preliminary |
| Typical Dose | 5-10 mg weekly |
| Frequency | Once or twice weekly |
| Key Goals | fat-loss, anti-aging |
How it works
Activates AMPK (the cellular energy sensor) and regulates metabolic homeostasis. Improves glucose metabolism and fat oxidation in a manner similar to exercise.
Benefits
- Metabolic regulation
- Exercise mimetic effects
- Improved insulin sensitivity
- Fat oxidation
Side effects
- Limited human data
- Potential GI effects
Dosing protocol
Typical Dose
5-10 mg weekly
Frequency
Once or twice weekly
Often used as an adjunct to exercise protocols.
Deeper on MOTS-c
Full breakdowns of every part of the MOTS-c research base.
What you will need
Basic supplies for reconstitution and subcutaneous injection.
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Bacteriostatic Water (30mL)
$8-15Required for reconstituting lyophilized peptides. 30mL is standard.
Insulin Syringes (1mL, 29ga)
$12-20 (100ct)1mL insulin syringes with 29-gauge needles for subcutaneous injection.
Alcohol Prep Pads
$5-10 (200ct)Sterile 70% isopropyl alcohol wipes for injection site prep.
Sharps Container
$8-15FDA-cleared sharps disposal container for used needles. See FDA guidance for compliant containers.
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Dosing quick-reference, key studies, and side effect management — in your inbox.
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Dosing quick-reference, key studies, and side effect management — in your inbox.
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Medical Disclaimer: This content is for informational and educational purposes only. It is not intended as medical advice or a substitute for professional medical consultation, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide protocol.