MOTS-c
(MOTS-c)Reviewed by Fat Man in the Arena · Updated March 2026
Key Takeaway
MOTS-c is a mitochondrial-derived peptide that regulates metabolic homeostasis and has been called an "exercise mimetic" for its ability to activate AMPK pathways.
How it works
Activates AMPK (the cellular energy sensor) and regulates metabolic homeostasis. Improves glucose metabolism and fat oxidation in a manner similar to exercise.
Benefits
- Metabolic regulation
- Exercise mimetic effects
- Improved insulin sensitivity
- Fat oxidation
Side effects
- Limited human data
- Potential GI effects
Dosing protocol
Typical Dose
5-10 mg weekly
Frequency
Once or twice weekly
Often used as an adjunct to exercise protocols.
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Medical Disclaimer: This content is for informational and educational purposes only. It is not intended as medical advice or a substitute for professional medical consultation, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide protocol.