GLP-1 Weight Loss Stack
The foundational weight loss protocol using GLP-1 receptor agonists with muscle preservation support. The most evidence-backed approach to significant weight loss.
Difficulty
beginner
Est. Cost
$200-600 (compounded) or $1,000+ (brand)
Duration
6-12+ months
Peptides
2 compounds
Protocol
| Peptide | Dose | Frequency | Timing | Role |
|---|---|---|---|---|
| Semaglutide | 0.25-2.4mg | Once weekly | Same day each week, any time | Primary appetite suppression and metabolic improvement |
| BPC-157 | 250-500mcg | Once daily | Morning, empty stomach | Gut lining support to mitigate GI side effects |
Notes
Start semaglutide at 0.25mg and titrate up every 4 weeks. BPC-157 is optional but helps with the nausea and GI issues common during dose escalation. Protein intake should be 1g per pound of body weight minimum to preserve lean mass. Resistance train 3-4x per week.
Related goals
Related Comparisons
Semaglutide vs Tirzepatide: Which GLP-1 Wins?
Semaglutide vs Retatrutide: Single vs Triple Agonist Compared
Semaglutide vs Liraglutide: Weekly vs Daily GLP-1 for Weight Loss
Semaglutide vs Survodutide: GLP-1 vs GLP-1/Glucagon Dual Agonist
Ozempic vs Wegovy: Same Drug, Different Doses — What You Need to Know
Retatrutide vs Tirzepatide vs Semaglutide (2026)
Related stacks
Free Peptide Weight Loss Guide
Semaglutide vs. tirzepatide vs. retatrutide. Dosing protocols, side effects, gray market sourcing, and what the clinical trials found.
Written by Alejandro Reyes
Founder & Lead Researcher
Reviewed by Peptide Nerds Editorial · Updated April 2026
Medical Disclaimer: Peptide stacks are not FDA-approved protocols. This information is for educational purposes only. Consult a qualified healthcare provider before combining any peptides.