GLP-1 Weight Loss Stack
The foundational weight loss protocol using GLP-1 receptor agonists with muscle preservation support. The most evidence-backed approach to significant weight loss.
Difficulty
beginner
Est. Cost
$200-600 (compounded) or $1,000+ (brand)
Duration
6-12+ months
Peptides
2 compounds
Protocol
| Peptide | Dose | Frequency | Timing | Role |
|---|---|---|---|---|
| Semaglutide | 0.25-2.4mg | Once weekly | Same day each week, any time | Primary appetite suppression and metabolic improvement |
| BPC-157 | 250-500mcg | Once daily | Morning, empty stomach | Gut lining support to mitigate GI side effects |
Notes
Start semaglutide at 0.25mg and titrate up every 4 weeks. BPC-157 is optional but helps with the nausea and GI issues common during dose escalation. Protein intake should be 1g per pound of body weight minimum to preserve lean mass. Resistance train 3-4x per week.
Related goals
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Reviewed by Fat Man in the Arena · Updated March 2026
Medical Disclaimer: Peptide stacks are not FDA-approved protocols. This information is for educational purposes only. Consult a qualified healthcare provider before combining any peptides.