Semaglutide Dosage Guide
FDA Approved
FM
Reviewed by Fat Man in the Arena · Updated March 2026
Not medical advice. Dosage information is provided for educational purposes based on published research. Always consult a qualified healthcare provider before starting any protocol. Full disclaimer.
Dosage overview
| Typical dose | 0.25 mg to 2.4 mg weekly (injection) |
| Frequency | Once weekly subcutaneous injection |
| Cycle length | Ongoing — weight regain common after discontinuation |
Dosing notes
Dose is titrated up gradually over 16-20 weeks to minimize GI side effects. Start at 0.25 mg/week for 4 weeks, then increase. The FDA-approved weight loss dose is 2.4 mg/week (Wegovy).
FDA-approved indications
Semaglutide is FDA-approved for: Type 2 diabetes (Ozempic), chronic weight management (Wegovy).
Off-label use should only be pursued under the guidance of a licensed healthcare provider.
Important safety information
Dosage ranges listed above are based on published clinical trial protocols. Individual dosing should be determined by a qualified healthcare provider based on your specific health profile, goals, and response to treatment.
- Start at the lowest effective dose and titrate up gradually
- Monitor for side effects, especially during dose increases
- Do not exceed researched dose ranges without medical supervision
Research references
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