Tesofensine
Written by Alejandro Reyes
Founder & Lead Researcher
Reviewed by Peptide Nerds Editorial · Updated April 2026
Key Takeaway
Tesofensine is a triple monoamine reuptake inhibitor (serotonin, norepinephrine, dopamine) that reduces appetite through central nervous system pathways different from GLP-1 agonists.
| Type | GLP-1 / Weight Loss |
| FDA Status | Research Only |
| Evidence Level | Moderate |
| Typical Dose | 0.25 mg to 0.5 mg daily |
| Frequency | Once daily oral |
| Key Goals | weight-loss, fat-loss |
How it works
Inhibits reuptake of serotonin, norepinephrine, and dopamine in the brain, reducing appetite and increasing thermogenesis through different pathways than GLP-1 agonists.
Benefits
- Oral capsule (no injection)
- Different mechanism than GLP-1s
- Can potentially be combined with GLP-1 agonists
Side effects
- Increased heart rate
- Dry mouth
- Insomnia
- Constipation
- Mood changes
Dosing protocol
Typical Dose
0.25 mg to 0.5 mg daily
Frequency
Once daily oral
Not FDA-approved. Available through some compounding pharmacies.
Deeper on Tesofensine
Full breakdowns of every part of the Tesofensine research base.
What you will need
Basic supplies for reconstitution and subcutaneous injection.
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Bacteriostatic Water (30mL)
$8-15Required for reconstituting lyophilized peptides. 30mL is standard.
Insulin Syringes (1mL, 29ga)
$12-20 (100ct)1mL insulin syringes with 29-gauge needles for subcutaneous injection.
Alcohol Prep Pads
$5-10 (200ct)Sterile 70% isopropyl alcohol wipes for injection site prep.
Sharps Container
$8-15FDA-cleared sharps disposal container for used needles.
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Medical Disclaimer: This content is for informational and educational purposes only. It is not intended as medical advice or a substitute for professional medical consultation, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide protocol.