Tesofensine
Reviewed by Fat Man in the Arena · Updated March 2026
Key Takeaway
Tesofensine is a triple monoamine reuptake inhibitor (serotonin, norepinephrine, dopamine) that reduces appetite through central nervous system pathways different from GLP-1 agonists.
How it works
Inhibits reuptake of serotonin, norepinephrine, and dopamine in the brain, reducing appetite and increasing thermogenesis through different pathways than GLP-1 agonists.
Benefits
- Oral capsule (no injection)
- Different mechanism than GLP-1s
- Can potentially be combined with GLP-1 agonists
Side effects
- Increased heart rate
- Dry mouth
- Insomnia
- Constipation
- Mood changes
Dosing protocol
Typical Dose
0.25 mg to 0.5 mg daily
Frequency
Once daily oral
Not FDA-approved. Available through some compounding pharmacies.
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Medical Disclaimer: This content is for informational and educational purposes only. It is not intended as medical advice or a substitute for professional medical consultation, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide protocol.