Cagrilintide
Written by Alejandro Reyes
Founder & Lead Researcher
Reviewed by Peptide Nerds Editorial · Updated April 2026
Key Takeaway
Cagrilintide is a long-acting amylin analog being developed by Novo Nordisk, studied in combination with semaglutide (CagriSema) for enhanced weight loss.
| Type | GLP-1 / Weight Loss |
| FDA Status | Clinical Trials |
| Evidence Level | Moderate |
| Typical Dose | 2.4 mg weekly (in combination) |
| Frequency | Once weekly |
| Key Goals | weight-loss |
How it works
Mimics the hormone amylin, which is co-secreted with insulin. Reduces appetite through hypothalamic signaling and slows gastric emptying via a pathway independent of GLP-1.
Benefits
- Complementary mechanism to GLP-1 agonists
- CagriSema combination shows greater weight loss than semaglutide alone
Side effects
- Nausea
- Injection site reactions
Dosing protocol
Typical Dose
2.4 mg weekly (in combination)
Frequency
Once weekly
Studied primarily in combination with semaglutide (CagriSema).
Deeper on Cagrilintide
Full breakdowns of every part of the Cagrilintide research base.
What you will need
Basic supplies for reconstitution and subcutaneous injection.
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Bacteriostatic Water (30mL)
$8-15Required for reconstituting lyophilized peptides. 30mL is standard.
Insulin Syringes (1mL, 29ga)
$12-20 (100ct)1mL insulin syringes with 29-gauge needles for subcutaneous injection.
Alcohol Prep Pads
$5-10 (200ct)Sterile 70% isopropyl alcohol wipes for injection site prep.
Sharps Container
$8-15FDA-cleared sharps disposal container for used needles.
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Medical Disclaimer: This content is for informational and educational purposes only. It is not intended as medical advice or a substitute for professional medical consultation, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide protocol.