NAD+
(NAD+)Reviewed by Fat Man in the Arena · Updated March 2026
Key Takeaway
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme essential for cellular energy production and DNA repair that declines significantly with age.
How it works
Critical cofactor for sirtuin enzymes involved in DNA repair, cellular stress response, and metabolic regulation. Supplementation aims to restore youthful NAD+ levels.
Benefits
- Cellular energy production
- DNA repair support
- Sirtuin activation
- Cognitive function support
Side effects
- Flushing
- Nausea
- Headache
- GI discomfort
Dosing protocol
Typical Dose
250-500 mg IV or 250 mg subcutaneous
Frequency
Weekly IV or daily subcutaneous
Also available as oral precursors (NMN, NR) with lower bioavailability.
Related peptides
Looking for weight loss peptides? See our complete guide to the best peptides for weight loss or compare semaglutide vs tirzepatide.
Weekly peptide research updates
New studies, GLP-1 news, protocol insights, and weight loss data — delivered every week. Free. No spam.
Medical Disclaimer: This content is for informational and educational purposes only. It is not intended as medical advice or a substitute for professional medical consultation, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide protocol.