NAD+

(NAD+)

Anti-Aging Research Only moderate evidence Track This Protocol

Written by Alejandro Reyes

Founder & Lead Researcher

Reviewed by Peptide Nerds Editorial · Updated April 2026

Key Takeaway

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme essential for cellular energy production and DNA repair that declines significantly with age.

Quick Facts
Type	Anti-Aging
FDA Status	Research Only
Evidence Level	Moderate
Typical Dose	250-500 mg IV or 250 mg subcutaneous
Frequency	Weekly IV or daily subcutaneous
Key Goals	anti-aging

How it works

Critical cofactor for sirtuin enzymes involved in DNA repair, cellular stress response, and metabolic regulation. Supplementation aims to restore youthful NAD+ levels.

Benefits

Cellular energy production
DNA repair support
Sirtuin activation
Cognitive function support

Side effects

Flushing
Nausea
Headache
GI discomfort

Dosing protocol

Typical Dose

250-500 mg IV or 250 mg subcutaneous

Frequency

Weekly IV or daily subcutaneous

Also available as oral precursors (NMN, NR) with lower bioavailability.

Track This Protocol

Deeper on NAD+

Full breakdowns of every part of the NAD+ research base.

NAD+ benefits

What the research shows, what it doesn't

NAD+ dosage guide

Loading, maintenance, cycling, reconstitution

NAD+ side effects

Safety profile, contraindications, what to watch

What you will need

Basic supplies for reconstitution and subcutaneous injection.

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Bacteriostatic Water (30mL)

$8-15

Required for reconstituting lyophilized peptides. 30mL is standard.

Insulin Syringes (1mL, 29ga)

$12-20 (100ct)

1mL insulin syringes with 29-gauge needles for subcutaneous injection.

Alcohol Prep Pads

$5-10 (200ct)

Sterile 70% isopropyl alcohol wipes for injection site prep.

Sharps Container

$8-15

FDA-cleared sharps disposal container for used needles.

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Goals

Energy & Stamina

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Medical Disclaimer: This content is for informational and educational purposes only. It is not intended as medical advice or a substitute for professional medical consultation, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide protocol.