Semax
Reviewed by Fat Man in the Arena · Updated March 2026
Key Takeaway
Semax is a synthetic peptide analog of ACTH(4-10) developed in Russia, used clinically there for cognitive enhancement, stroke recovery, and neuroprotection.
How it works
Modulates BDNF and NGF expression, enhancing neuroplasticity. Also affects dopamine and serotonin systems.
Benefits
- Cognitive enhancement
- Neuroprotection
- Anxiety reduction
- Approved in Russia for clinical use
Side effects
- Nasal irritation
- Headache (rare)
- Generally well-tolerated
Dosing protocol
Typical Dose
200-600 mcg daily
Frequency
Once or twice daily intranasal
Available as nasal spray. Approved in Russia.
Stacks with Semax
Goals
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Medical Disclaimer: This content is for informational and educational purposes only. It is not intended as medical advice or a substitute for professional medical consultation, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide protocol.