Semax
Written by Alejandro Reyes
Founder & Lead Researcher
Reviewed by Peptide Nerds Editorial · Updated April 2026
Key Takeaway
Semax is a synthetic peptide analog of ACTH(4-10) developed in Russia, used clinically there for cognitive enhancement, stroke recovery, and neuroprotection.
| Type | Cognitive |
| FDA Status | Research Only |
| Evidence Level | Moderate |
| Typical Dose | 200-600 mcg daily |
| Frequency | Once or twice daily intranasal |
| Key Goals | cognitive |
How it works
Modulates BDNF and NGF expression, enhancing neuroplasticity. Also affects dopamine and serotonin systems.
Benefits
- Cognitive enhancement
- Neuroprotection
- Anxiety reduction
- Approved in Russia for clinical use
Side effects
- Nasal irritation
- Headache (rare)
- Generally well-tolerated
Dosing protocol
Typical Dose
200-600 mcg daily
Frequency
Once or twice daily intranasal
Available as nasal spray. Approved in Russia.
Deeper on Semax
Full breakdowns of every part of the Semax research base.
What you will need
Basic supplies for reconstitution and subcutaneous injection.
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Bacteriostatic Water (30mL)
$8-15Required for reconstituting lyophilized peptides. 30mL is standard.
Insulin Syringes (1mL, 29ga)
$12-20 (100ct)1mL insulin syringes with 29-gauge needles for subcutaneous injection.
Alcohol Prep Pads
$5-10 (200ct)Sterile 70% isopropyl alcohol wipes for injection site prep.
Sharps Container
$8-15FDA-cleared sharps disposal container for used needles.
Get the Semax cheat sheet
Dosing quick-reference, key studies, and side effect management — in your inbox.
Get the Semax cheat sheet
Dosing quick-reference, key studies, and side effect management — in your inbox.
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Medical Disclaimer: This content is for informational and educational purposes only. It is not intended as medical advice or a substitute for professional medical consultation, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide protocol.