Melanotan II
Reviewed by Fat Man in the Arena · Updated March 2026
Key Takeaway
Melanotan II is a synthetic melanocortin peptide that stimulates melanin production (tanning) and has sexual arousal and appetite-suppressing effects.
How it works
Non-selective melanocortin receptor agonist that stimulates MC1R (melanin/tanning), MC3R/MC4R (sexual function, appetite), producing multiple effects.
Benefits
- Skin tanning without UV
- Appetite suppression
- Sexual function enhancement
Side effects
- Nausea
- Facial flushing
- New mole formation
- Darkening of existing moles (monitor for melanoma)
Dosing protocol
Typical Dose
250-500 mcg per injection
Frequency
Daily during loading, then maintenance
NOT FDA-approved. Monitor moles closely. Consult dermatologist.
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Medical Disclaimer: This content is for informational and educational purposes only. It is not intended as medical advice or a substitute for professional medical consultation, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide protocol.