PT-141
Written by Alejandro Reyes
Founder & Lead Researcher
Reviewed by Peptide Nerds Editorial · Updated April 2026
Key Takeaway
PT-141 (Bremelanotide) is FDA-approved for hypoactive sexual desire disorder in women. It works through the melanocortin system rather than the vascular system like Viagra.
| Type | Other |
| FDA Status | FDA Approved |
| Evidence Level | Strong |
| Typical Dose | 1.75 mg per use |
| Frequency | As needed, at least 45 min before activity |
| Key Goals |
How it works
Activates melanocortin-4 receptors in the brain to increase sexual desire through central nervous system pathways.
Benefits
- FDA-approved for HSDD in women
- Works through desire pathway (not vascular)
- Effective in both men and women
Side effects
- Nausea (most common)
- Flushing
- Headache
- Skin darkening
Dosing protocol
Typical Dose
1.75 mg per use
Frequency
As needed, at least 45 min before activity
FDA-approved as Vyleesi. Max 8 doses per month.
Deeper on PT-141
Full breakdowns of every part of the PT-141 research base.
What you will need
Basic supplies for reconstitution and subcutaneous injection.
This page contains affiliate links. Learn more
Bacteriostatic Water (30mL)
$8-15Required for reconstituting lyophilized peptides. 30mL is standard.
Insulin Syringes (1mL, 29ga)
$12-20 (100ct)1mL insulin syringes with 29-gauge needles for subcutaneous injection.
Alcohol Prep Pads
$5-10 (200ct)Sterile 70% isopropyl alcohol wipes for injection site prep.
Sharps Container
$8-15FDA-cleared sharps disposal container for used needles.
Get the PT-141 cheat sheet
Dosing quick-reference, key studies, and side effect management — in your inbox.
FDA status
FDA Approved for: Hypoactive sexual desire disorder in premenopausal women (Vyleesi)
Get the PT-141 cheat sheet
Dosing quick-reference, key studies, and side effect management — in your inbox.
Compare PT-141
Stacks with PT-141
Goals
Related peptides
Looking for weight loss peptides? See our complete guide to the best peptides for weight loss or compare semaglutide vs tirzepatide .
Get the Peptide Starter Kit (free)
Quick-start guide to GLP-1 peptides, dosing basics, and what to ask your doctor.
Medical Disclaimer: This content is for informational and educational purposes only. It is not intended as medical advice or a substitute for professional medical consultation, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide protocol.