TB-500
(TB-500)Reviewed by Fat Man in the Arena · Updated March 2026
Key Takeaway
TB-500 is a synthetic version of a segment of Thymosin Beta-4, a naturally occurring protein involved in tissue repair, cell migration, and inflammation regulation.
How it works
TB-500 upregulates actin, a cell-building protein that plays a role in cell migration and proliferation. It promotes angiogenesis, reduces inflammation, and supports tissue repair by enabling cells to move to injury sites more effectively.
Benefits
- Reduced inflammation
- Accelerated wound healing
- Improved flexibility and range of motion
- Cardiac tissue repair potential
- Hair regrowth reported anecdotally
Side effects
- Headache
- Mild nausea
- Lethargy
- Limited human safety data
Dosing protocol
Typical Dose
2-5 mg per week
Frequency
Two injections per week (loading), then once weekly
Cycle Length
4-6 weeks loading, 2-4 weeks maintenance
Often stacked with BPC-157 for synergistic healing effects. Not FDA-approved.
Key research
Thymosin beta4 promotes dermal healing
Annals of the New York Academy of Sciences (2007) — PubMed
Thymosin beta-4 accelerated dermal wound healing by promoting cell migration, collagen deposition, and angiogenesis in animal models.
Frequently asked questions
TB-500 is a synthetic fragment of the naturally occurring protein Thymosin Beta-4. It contains the active region responsible for healing properties but is shorter and more practical to manufacture. They share the same mechanism of action, though full-length Thymosin Beta-4 may have additional biological activities.
Compare TB-500
Stacks with TB-500
Goals
Related peptides
Looking for weight loss peptides? See our complete guide to the best peptides for weight loss or compare semaglutide vs tirzepatide.
Weekly peptide research updates
New studies, GLP-1 news, protocol insights, and weight loss data — delivered every week. Free. No spam.
Medical Disclaimer: This content is for informational and educational purposes only. It is not intended as medical advice or a substitute for professional medical consultation, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide protocol.