CJC-1295
(CJC-1295)Reviewed by Fat Man in the Arena · Updated March 2026
Key Takeaway
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) that extends the half-life of natural GH release. Often combined with ipamorelin for amplified growth hormone output.
How it works
Mimics GHRH to stimulate pituitary GH release. The DAC (Drug Affinity Complex) version binds to albumin, extending its half-life to 6-8 days. The no-DAC version (mod GRF 1-29) has a shorter duration matching natural GH pulse patterns.
Benefits
- Sustained growth hormone elevation
- Improved body composition
- Enhanced recovery
- Better sleep quality
- Synergistic with GHRPs like ipamorelin
Side effects
- Water retention
- Flushing
- Headache
- Dizziness
Dosing protocol
Typical Dose
100-300 mcg per injection (no DAC)
Frequency
1-3 times daily
Cycle Length
8-12 weeks
No-DAC version (mod GRF 1-29) preferred for more natural pulsatile GH release. Best combined with ipamorelin.
Key research
Prolonged stimulation of growth hormone secretion by CJC-1295
Journal of Clinical Endocrinology & Metabolism (2006) — PubMed
CJC-1295 with DAC produced sustained 2-10 fold increases in GH and IGF-1 levels for 6+ days after a single injection in healthy adults.
Frequently asked questions
CJC-1295 with DAC has a Drug Affinity Complex that extends its half-life to 6-8 days, producing sustained elevated GH levels. Without DAC (mod GRF 1-29), the half-life is about 30 minutes, creating more natural pulsatile GH release patterns preferred by most users.
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Medical Disclaimer: This content is for informational and educational purposes only. It is not intended as medical advice or a substitute for professional medical consultation, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide protocol.